Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) ChingArticle Published on 2023-04-012023-06-23 Journal: Phytochemistry [Category] 신종인플루엔자, [키워드] antiviral activities Dryopteridaceae Dryopteris atrata Phloroglucinol derivatives Structural elucidation. [DOI] 10.1016/j.phytochem.2023.113585 PMC 바로가기
Antiviral COVID-19 protein and molecular docking: In silico characterization of various antiviral compounds extracted from Arisaema jacquemontii BlumeArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Public Health [Category] 치료제, [키워드] 6LU7 A. jacquemontii Blume affinity Analysis Anti-COVID protein antimalarial antioxidant Antiviral antiviral activities Antiviral compound Araceae Arisaema binding binding affinity binding energy Cobra Cobra lily Compound compounds COVID-19 COVID-19 therapeutics Diseases docked docking effective evaluated FIVE Gas Chromatography-Mass Spectrometry GC-MS highest in silico Interaction interactions molecular phytochemical. protease Protein SARS virus selected shown these compound treat viral infections [DOI] 10.3389/fpubh.2022.964741 PMC 바로가기
In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against Mpro, RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by NatureArticle Published on 2022-08-292022-11-15 Journal: Toxins [Category] SARS, 치료제, [키워드] active against added addition Analysis antiviral activities benzoxazinoid calculated candidate complex complexes Compound COVID-19 derivative derivatives described docking docking score Dynamics ENhance evaluated fluctuation generate Hydrogen bond in silico interactions kinetic M pro molecular molecular docking molecular dynamics MPro Nature Phytotoxin protease Protein protein-ligand replicase RMSD RNA SARS-CoV-2 selected Sesquiterpene sesquiterpene. shown spike spike glycoprotein Spike protein stability tested the spike protein virus were assessed [DOI] 10.3390/toxins14090599 PMC 바로가기
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral ActivitySec61 억제제 아프라톡신 S4는 SARS-CoV-2를 강력하게 억제하고 광범위한 항바이러스 활성을 나타냅니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] activity anticancer Antiviral antiviral activities antiviral activity blocked broad-spectrum antivirals cellular characterization COVID-19 Dengue dengue virus double-membrane vesicles dsRNA elicit Endoplasmic reticulum high potency Host host-directed therapeutics. human cells impacted in vitro in vivo Influenza influenza A influenza A virus inhibited inhibitor Microscopy Nile Pandemics Prevent prevented Protein Proteins reduced SARS-CoV-2 Sec61 shown Spike protein tested the spike protein translocation transmission electron microscopy vesicles Viral viral infection Viral protein viral replication virus West Zika [DOI] 10.1021/acsinfecdis.2c00008 PMC 바로가기 [Article Type] Article
Anisotine and amarogentin as promising inhibitory candidates against SARS-CoV-2 proteins: a computational investigationSARS-CoV-2 단백질에 대한 유망한 억제 후보로서의 아니소틴 및 아마로젠틴: 전산 조사Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amarogentin Analysis antiviral activities antiviral activity approach binding energy binding pocket binding pockets candidate Candidates caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug effective enzyme Extensive feature followed by global public health Host in silico in vitro in vivo inhibitor inhibitors inhibitory Justicia adhatoda limit M pro molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Ocimum Ocimum sanctum pandemic physicochemical Phytocompounds plant present protease Protein RdRP reported Research research finding researcher RNA-dependent RNA polymerase robust SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 RdRp SARS-CoV-2 spike significantly higher Spike protein Spread Swertia Swertia chirata target therapeutic therapeutic candidates. these compound these compounds Toxicity Viral protein Viral proteins viral replication virus [DOI] 10.1080/07391102.2020.1860133 PMC 바로가기 [Article Type] Article
Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compoundsSARS-CoV-2에 대한 벤잘아세토페논 유도체의 잠재적 다중 표적 생리활성 화합물의 전산 조사Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro 3CL(pro) addition Anti-SARS-CoV-2 Activity Antiviral antiviral activities Antiviral agents AutoDock Benzalacetophenones binding affinity binding energy binding free energy biological processes Candidates cellular components Compound COVID-19 derivative develop Diseases domain down-regulated enrichment analysis evaluated FIVE flavonoids free energy highest highest binding affinity identify Immune boost immune system Immunity immunostimulant Interaction lab modulated modulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular functions Molecular mechanics multiple pathway multiple pathways network network pharmacology nine non-infectious Papain Papain-like protease pathway Pathways Patient pharmacological PL(pro) precursor precursors protease Protein recorded reflected regulated retrieved SARS-CoV-2 scored screened Simulation spike Spike protein spike protein. surface area target upregulated was performed [DOI] 10.1016/j.compbiomed.2022.105668 PMC 바로가기 [Article Type] Article
Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles환경적으로 아지스로마이신 제약 폐수 관리 및 로딩된 아지트로마이신@적철석 나노입자의 상승적 생체 적합성 접근법Article Published on 2022-06-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] activity Adsorption adsorption capacity Antibacterial antibacterial activity antibiotic anticancer Antiviral antiviral activities antiviral activity approach approach Azithromycin Bacteria biosynthesized Cancer cell line Concentration condition conducted contaminant Contamination COVID-19 virus cytotoxicity described dose Echinacea experiments gram Gram-negative bacteria Hematite HepG2 investigated isothermal kinetic Kinetics Langmuir model management manifested parameter pharmaceutical platform R 2 removal reported SARS-CoV-2 strain synergistic synergistic effect therapeutic therapeutic index thermodynamic Treatment virus [DOI] 10.1038/s41598-022-14997-y PMC 바로가기 [Article Type] Article
Antiviral Cyclopropane Acids from Deep-Sea-Derived Fungus Aspergillus sydowiiArticle Published on 2022-06-232023-06-23 Journal: Marine Drugs [Category] 신종인플루엔자, [키워드] antiviral activities Aspergillus sydowii cyclopropane deep-sea-derived fungus. H1N1 [DOI] 10.3390/md20070410 PMC 바로가기
Pyridine Compounds with Antimicrobial and Antiviral Activities항균 및 항바이러스 활성을 갖는 피리딘 화합물Review Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activity analgesic Anti-inflammatory anticonvulsant antidiabetic antimicrobial antioxidant Antiviral antiviral activities binding caused Compound compounds correlation COVID-19 pandemic determine group groups heterocyclic compounds hydrocarbon IMPROVE Interaction life-threatening linker molecular docking studies molecules nucleus priority Protein pyridine Research SARS-CoV-2 virus singular specific protein synthesis synthesis. the SARS-CoV-2 virus therapeutic water [DOI] 10.3390/ijms23105659 PMC 바로가기 [Article Type] Review
Pseudanabaena galeata CCNP1313-Biological Activity and Peptides ProductionPseudanabaena galeata CCNP1313-생물학적 활성 및 펩티드 생산Article Published on 2022-05-062022-09-11 Journal: Toxins [Category] COVID19(2023년), SARS, 치료기술, [키워드] A549 activity African green monkey analysis anticancer anticancer activity Antiviral antiviral activities antiviral activity Apoptosis Baltic Sea Breast cancer cancer cell line cancer cell lines cell line complex component Compound cyanobacteria cytotoxicity ecosystem Effect enzyme fibroblasts fraction Fractions green monkey HCoV HCoV-OC43 HCT-8 induction of apoptosis inhibitors kidney less MCF-7 metabolite metabolites new peptides. peptides potent produced Production Pseudanabaena galeata SARS-CoV-2 strain Structure tested TMPRSS2 toxins virus were used [DOI] 10.3390/toxins14050330 PMC 바로가기 [Article Type] Article